Fare Guide

Estimated lowest fares found within 7 days

Cheapest Airline Copa Airlines
Cheapest Month June
Cheapest Day of the Week Friday
Cheapest Airline Copa Airlines

The cheapest airline(s) flying from Santo Domingo to Medellin is Copa Airlines.

  • Copa Airlines Copa Airlines
  • Arajet Arajet
  • Avianca Avianca
  • Euroairlines Euroairlines
  • Spirit Airlines Spirit Airlines
  • JetBlue Airways JetBlue Airways
  • American Airlines American Airlines
  • United Airlines United Airlines
Cheapest Month June

Travel Period: June 2025 - May 2026

The cheapest month(s) to fly from Santo Domingo to Medellin is June.

  • Jun 2025
  • Jul 2025
  • Aug 2025
  • Sep 2025
  • Oct 2025
  • Nov 2025
  • Dec 2025
  • Jan 2026
  • Feb 2026
  • Mar 2026
  • Apr 2026
  • May 2026
Cheapest Day of the Week Friday

The cheapest day(s) of the week to fly from Santo Domingo to Medellin is Friday.

  • Sun Sunday
  • Mon Monday
  • Tue Tuesday
  • Wed Wednesday
  • Thu Thursday
  • Fri Friday
  • Sat Saturday

Flight Schedules

Last Updated: Fri, 2 May, 2025

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    • Airline Filter by Airline
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      • Availability
        • M
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      • 07:45 SDQ
        09:20 MDE
        2Hrs, 35m Direct
      • SDQSanto Domingo Las Americas Airport 07:45 - MDE 09:20 2h 35m Direct
      • SDQSanto Domingo Las Americas Airport 07:45
      • MDEMedellin Jose Maria Cordova Intl Airport 09:20
      • 2h 35m
      • Direct
      • Arajet (DM 1734)Boeing 737 Max 8 Passenger
      • Arajet (DM 1734)
        • -
        • -
        • -
        • T
        • -
        • S
        • S
      • Boeing 737 Max 8 Passenger
      • 12:05 SDQ
        13:40 MDE
        2Hrs, 35m Direct
      • SDQSanto Domingo Las Americas Airport 12:05 - MDE 13:40 2h 35m Direct
      • SDQSanto Domingo Las Americas Airport 12:05
      • MDEMedellin Jose Maria Cordova Intl Airport 13:40
      • 2h 35m
      • Direct
      • Arajet (DM 1736)Boeing 737 Max 8 Passenger
      • Arajet (DM 1736)
        • -
        • -
        • W
        • -
        • -
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      • Boeing 737 Max 8 Passenger
      • 14:37 SDQ
        16:06 MDE
        2Hrs, 29m Direct
      • SDQSanto Domingo Las Americas Airport 14:37 - MDE 16:06 2h 29m Direct
      • SDQSanto Domingo Las Americas Airport 14:37
      • MDEMedellin Jose Maria Cordova Intl Airport 16:06
      • 2h 29m
      • Direct
      • Wingo (P5 7421)Boeing 737 800
      • Wingo (P5 7421)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • Boeing 737 800
      • 15:22 SDQ
        16:57 MDE
        2Hrs, 35m Direct
      • SDQSanto Domingo Las Americas Airport 15:22 - MDE 16:57 2h 35m Direct
      • SDQSanto Domingo Las Americas Airport 15:22
      • MDEMedellin Jose Maria Cordova Intl Airport 16:57
      • 2h 35m
      • Direct
      • Arajet (DM 1734)Boeing 737 Max 8 Passenger
      • Arajet (DM 1734)
        • -
        • T
        • -
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      • Boeing 737 Max 8 Passenger
      • 16:22 SDQ
        17:51 MDE
        2Hrs, 29m Direct
      • SDQSanto Domingo Las Americas Airport 16:22 - MDE 17:51 2h 29m Direct
      • SDQSanto Domingo Las Americas Airport 16:22
      • MDEMedellin Jose Maria Cordova Intl Airport 17:51
      • 2h 29m
      • Direct
      • Wingo (P5 7421)Boeing 737 800
      • Wingo (P5 7421)
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        • -
        • -
        • -
        • -
        • -
      • Boeing 737 800
      • 18:05 SDQ
        19:40 MDE
        2Hrs, 35m Direct
      • SDQSanto Domingo Las Americas Airport 18:05 - MDE 19:40 2h 35m Direct
      • SDQSanto Domingo Las Americas Airport 18:05
      • MDEMedellin Jose Maria Cordova Intl Airport 19:40
      • 2h 35m
      • Direct
      • Arajet (DM 1736)Boeing 737 Max 8 Passenger
      • Arajet (DM 1736)
        • M
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        • -
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        • -
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      • Boeing 737 Max 8 Passenger
      • 19:07 SDQ
        20:42 MDE
        2Hrs, 35m Direct
      • SDQSanto Domingo Las Americas Airport 19:07 - MDE 20:42 2h 35m Direct
      • SDQSanto Domingo Las Americas Airport 19:07
      • MDEMedellin Jose Maria Cordova Intl Airport 20:42
      • 2h 35m
      • Direct
      • Arajet (DM 1738)Boeing 737 Max 8 Passenger
      • Arajet (DM 1738)
        • -
        • -
        • -
        • -
        • F
        • -
        • -
      • Boeing 737 Max 8 Passenger
      • 05:21 SDQ
        10:29 MDE
        6Hrs, 08m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 05:21 - MDE 10:29 6h 08m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 05:21
        PTYPanama City Tocumen International Airport 09:04
      • PTYPanama City Tocumen International Airport 06:58
        MDEMedellin Jose Maria Cordova Intl Airport 10:29
      • 6h 08m (2h 06m)
      • 1 Stop PTY · Panama City 2h 06m
      • Copa Airlines (CM 108)Boeing 737 800
        Copa Airlines (CM 855)Boeing 737 700
      • Copa Airlines (CM 108)
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        • -
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        • -
        • -
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      • 05:21 SDQ
        10:29 MDE
        6Hrs, 08m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 05:21 - MDE 10:29 6h 08m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 05:21
        PTYPanama City Tocumen International Airport 09:04
      • PTYPanama City Tocumen International Airport 06:58
        MDEMedellin Jose Maria Cordova Intl Airport 10:29
      • 6h 08m (2h 06m)
      • 1 Stop PTY · Panama City 2h 06m
      • Copa Airlines (CM 108)Boeing 737 700
        Copa Airlines (CM 855)Boeing 737 700
      • Copa Airlines (CM 108)
        • -
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        • -
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      • 05:21 SDQ
        10:56 MDE
        6Hrs, 35m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 05:21 - MDE 10:56 6h 35m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 05:21
        PTYPanama City Tocumen International Airport 09:31
      • PTYPanama City Tocumen International Airport 06:58
        MDEMedellin Jose Maria Cordova Intl Airport 10:56
      • 6h 35m (2h 33m)
      • 1 Stop PTY · Panama City 2h 33m
      • Copa Airlines (CM 108)Boeing 737 800
        Copa Airlines (CM 397)Boeing 737 800
      • Copa Airlines (CM 108)
        • -
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      • 05:21 SDQ
        10:56 MDE
        6Hrs, 35m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 05:21 - MDE 10:56 6h 35m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 05:21
        PTYPanama City Tocumen International Airport 09:31
      • PTYPanama City Tocumen International Airport 06:58
        MDEMedellin Jose Maria Cordova Intl Airport 10:56
      • 6h 35m (2h 33m)
      • 1 Stop PTY · Panama City 2h 33m
      • Copa Airlines (CM 108)Boeing 737 700
        Copa Airlines (CM 397)Boeing 737 800
      • Copa Airlines (CM 108)
        • -
        • -
        • -
        • T
        • -
        • S
        • S
      • 05:21 SDQ
        10:29 MDE
        6Hrs, 08m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 05:21 - MDE 10:29 6h 08m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 05:21
        PTYPanama City Tocumen International Airport 09:04
      • PTYPanama City Tocumen International Airport 06:58
        MDEMedellin Jose Maria Cordova Intl Airport 10:29
      • 6h 08m (2h 06m)
      • 1 Stop PTY · Panama City 2h 06m
      • Copa Airlines (CM 108)Boeing 737 700
        Copa Airlines (CM 855)Boeing 737 Max 8 Passenger
      • Copa Airlines (CM 108)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 08:53 SDQ
        14:15 MDE
        6Hrs, 22m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 08:53 - MDE 14:15 6h 22m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 08:53
        PTYPanama City Tocumen International Airport 12:50
      • PTYPanama City Tocumen International Airport 10:30
        MDEMedellin Jose Maria Cordova Intl Airport 14:15
      • 6h 22m (2h 20m)
      • 1 Stop PTY · Panama City 2h 20m
      • Copa Airlines (CM 267)Boeing 737 800
        Copa Airlines (CM 502)Boeing 737 800
      • Copa Airlines (CM 267)
        • M
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        • S
        • S
      • 11:45 SDQ
        16:45 MDE
        6Hrs, 00m 1 Stop (BOG)
      • SDQSanto Domingo Las Americas Airport 11:45 - MDE 16:45 6h 1 Stop (BOG) Bogota
      • SDQSanto Domingo Las Americas Airport 11:45
        BOGBogota Airport 15:45
      • BOGBogota Airport 13:20
        MDEMedellin Jose Maria Cordova Intl Airport 16:45
      • 6h (2h 25m)
      • 1 Stop BOG · Bogota 2h 25m
      • Avianca (AV 209)Airbus
        Avianca (AV 9324)Airbus
      • Avianca (AV 209)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 11:45 SDQ
        16:12 MDE
        5Hrs, 27m 1 Stop (BOG)
      • SDQSanto Domingo Las Americas Airport 11:45 - MDE 16:12 5h 27m 1 Stop (BOG) Bogota
      • SDQSanto Domingo Las Americas Airport 11:45
        BOGBogota Airport 15:09
      • BOGBogota Airport 13:20
        MDEMedellin Jose Maria Cordova Intl Airport 16:12
      • 5h 27m (1h 49m)
      • 1 Stop BOG · Bogota 1h 49m
      • Avianca (AV 209)Airbus
        Avianca (AV 9326)Airbus
      • Avianca (AV 209)
        • M
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      • 11:45 SDQ
        15:48 MDE
        5Hrs, 03m 1 Stop (BOG)
      • SDQSanto Domingo Las Americas Airport 11:45 - MDE 15:48 5h 03m 1 Stop (BOG) Bogota
      • SDQSanto Domingo Las Americas Airport 11:45
        BOGBogota Airport 14:51
      • BOGBogota Airport 13:20
        MDEMedellin Jose Maria Cordova Intl Airport 15:48
      • 5h 03m (1h 31m)
      • 1 Stop BOG · Bogota 1h 31m
      • Avianca (AV 209)Airbus
        Avianca (AV 9310)Airbus
      • Avianca (AV 209)
        • M
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      • 11:45 SDQ
        16:45 MDE
        6Hrs, 00m 1 Stop (BOG)
      • SDQSanto Domingo Las Americas Airport 11:45 - MDE 16:45 6h 1 Stop (BOG) Bogota
      • SDQSanto Domingo Las Americas Airport 11:45
        BOGBogota Airport 15:45
      • BOGBogota Airport 13:20
        MDEMedellin Jose Maria Cordova Intl Airport 16:45
      • 6h (2h 25m)
      • 1 Stop BOG · Bogota 2h 25m
      • Avianca (AV 209)Airbus
        Avianca (AV 9324)Airbus
      • Avianca (AV 209)
        • -
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      • 11:52 SDQ
        17:01 MDE
        6Hrs, 09m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 11:52 - MDE 17:01 6h 09m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 11:52
        PTYPanama City Tocumen International Airport 15:36
      • PTYPanama City Tocumen International Airport 13:29
        MDEMedellin Jose Maria Cordova Intl Airport 17:01
      • 6h 09m (2h 07m)
      • 1 Stop PTY · Panama City 2h 07m
      • Copa Airlines (CM 129)Boeing 737 Max 9 Passenger
        Copa Airlines (CM 156)Boeing 737 800
      • Copa Airlines (CM 129)
        • -
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        • -
        • F
        • S
        • S
      • 11:52 SDQ
        17:01 MDE
        6Hrs, 09m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 11:52 - MDE 17:01 6h 09m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 11:52
        PTYPanama City Tocumen International Airport 15:36
      • PTYPanama City Tocumen International Airport 13:29
        MDEMedellin Jose Maria Cordova Intl Airport 17:01
      • 6h 09m (2h 07m)
      • 1 Stop PTY · Panama City 2h 07m
      • Copa Airlines (CM 129)Boeing 737 800
        Copa Airlines (CM 156)Boeing 737 800
      • Copa Airlines (CM 129)
        • M
        • -
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        • T
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      • 14:05 SDQ
        20:14 MDE
        7Hrs, 09m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 14:05 - MDE 20:14 7h 09m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 14:05
        PTYPanama City Tocumen International Airport 18:49
      • PTYPanama City Tocumen International Airport 15:42
        MDEMedellin Jose Maria Cordova Intl Airport 20:14
      • 7h 09m (3h 07m)
      • 1 Stop PTY · Panama City 3h 07m
      • Copa Airlines (CM 299)Boeing 737 800
        Copa Airlines (CM 163)Boeing 737 800
      • Copa Airlines (CM 299)
        • M
        • T
        • -
        • -
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        • -
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      • 14:05 SDQ
        19:58 MDE
        6Hrs, 53m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 14:05 - MDE 19:58 6h 53m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 14:05
        PTYPanama City Tocumen International Airport 18:33
      • PTYPanama City Tocumen International Airport 15:42
        MDEMedellin Jose Maria Cordova Intl Airport 19:58
      • 6h 53m (2h 51m)
      • 1 Stop PTY · Panama City 2h 51m
      • Copa Airlines (CM 299)Boeing 737 800
        Copa Airlines (CM 208)Boeing 737 800
      • Copa Airlines (CM 299)
        • M
        • T
        • -
        • T
        • -
        • S
        • -
      • 14:05 SDQ
        19:58 MDE
        6Hrs, 53m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 14:05 - MDE 19:58 6h 53m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 14:05
        PTYPanama City Tocumen International Airport 18:33
      • PTYPanama City Tocumen International Airport 15:42
        MDEMedellin Jose Maria Cordova Intl Airport 19:58
      • 6h 53m (2h 51m)
      • 1 Stop PTY · Panama City 2h 51m
      • Copa Airlines (CM 299)Boeing 737 Max 9 Passenger
        Copa Airlines (CM 208)Boeing 737 800
      • Copa Airlines (CM 299)
        • -
        • -
        • -
        • -
        • F
        • -
        • -
      • 14:05 SDQ
        19:58 MDE
        6Hrs, 53m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 14:05 - MDE 19:58 6h 53m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 14:05
        PTYPanama City Tocumen International Airport 18:33
      • PTYPanama City Tocumen International Airport 15:42
        MDEMedellin Jose Maria Cordova Intl Airport 19:58
      • 6h 53m (2h 51m)
      • 1 Stop PTY · Panama City 2h 51m
      • Copa Airlines (CM 299)Boeing 737 Max 9 Passenger
        Copa Airlines (CM 208)Boeing 737 Max 8 Passenger
      • Copa Airlines (CM 299)
        • -
        • -
        • W
        • -
        • -
        • -
        • -
      • 14:05 SDQ
        19:58 MDE
        6Hrs, 53m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 14:05 - MDE 19:58 6h 53m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 14:05
        PTYPanama City Tocumen International Airport 18:33
      • PTYPanama City Tocumen International Airport 15:42
        MDEMedellin Jose Maria Cordova Intl Airport 19:58
      • 6h 53m (2h 51m)
      • 1 Stop PTY · Panama City 2h 51m
      • Copa Airlines (CM 299)Boeing 737 800
        Copa Airlines (CM 208)Boeing 737 700
      • Copa Airlines (CM 299)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 14:05 SDQ
        20:14 MDE
        7Hrs, 09m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 14:05 - MDE 20:14 7h 09m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 14:05
        PTYPanama City Tocumen International Airport 18:49
      • PTYPanama City Tocumen International Airport 15:42
        MDEMedellin Jose Maria Cordova Intl Airport 20:14
      • 7h 09m (3h 07m)
      • 1 Stop PTY · Panama City 3h 07m
      • Copa Airlines (CM 299)Boeing 737 Max 9 Passenger
        Copa Airlines (CM 163)Boeing 737 800
      • Copa Airlines (CM 299)
        • -
        • -
        • W
        • -
        • -
        • -
        • -
      • 17:37 SDQ
        22:52 MDE
        6Hrs, 15m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 17:37 - MDE 22:52 6h 15m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 17:37
        PTYPanama City Tocumen International Airport 21:27
      • PTYPanama City Tocumen International Airport 19:14
        MDEMedellin Jose Maria Cordova Intl Airport 22:52
      • 6h 15m (2h 13m)
      • 1 Stop PTY · Panama City 2h 13m
      • Copa Airlines (CM 464)Boeing 737 800
        Copa Airlines (CM 155)Boeing 737 800
      • Copa Airlines (CM 464)
        • -
        • T
        • -
        • T
        • -
        • -
        • -
      • 17:37 SDQ
        22:52 MDE
        6Hrs, 15m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 17:37 - MDE 22:52 6h 15m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 17:37
        PTYPanama City Tocumen International Airport 21:27
      • PTYPanama City Tocumen International Airport 19:14
        MDEMedellin Jose Maria Cordova Intl Airport 22:52
      • 6h 15m (2h 13m)
      • 1 Stop PTY · Panama City 2h 13m
      • Copa Airlines (CM 464)Boeing 737 Max 9 Passenger
        Copa Airlines (CM 155)Boeing 737 700
      • Copa Airlines (CM 464)
        • M
        • -
        • -
        • -
        • F
        • -
        • -
      • 17:37 SDQ
        22:52 MDE
        6Hrs, 15m 1 Stop (PTY)
      • SDQSanto Domingo Las Americas Airport 17:37 - MDE 22:52 6h 15m 1 Stop (PTY) Panama City
      • SDQSanto Domingo Las Americas Airport 17:37
        PTYPanama City Tocumen International Airport 21:27
      • PTYPanama City Tocumen International Airport 19:14
        MDEMedellin Jose Maria Cordova Intl Airport 22:52
      • 6h 15m (2h 13m)
      • 1 Stop PTY · Panama City 2h 13m
      • Copa Airlines (CM 464)Boeing 737 800
        Copa Airlines (CM 155)Boeing 737 700
      • Copa Airlines (CM 464)
        • -
        • -
        • -
        • -
        • -
        • S
        • S
      • 18:10 SDQ
        23:17 MDE
        6Hrs, 07m 1 Stop (BOG)
      • SDQSanto Domingo Las Americas Airport 18:10 - MDE 23:17 6h 07m 1 Stop (BOG) Bogota
      • SDQSanto Domingo Las Americas Airport 18:10
        BOGBogota Airport 22:20
      • BOGBogota Airport 19:50
        MDEMedellin Jose Maria Cordova Intl Airport 23:17
      • 6h 07m (2h 30m)
      • 1 Stop BOG · Bogota 2h 30m
      • Avianca (AV 251)Airbus
        Avianca (AV 8449)Airbus
      • Avianca (AV 251)
        • -
        • T
        • -
        • T
        • -
        • S
        • S
      • 18:10 SDQ
        22:26 MDE
        5Hrs, 16m 1 Stop (BOG)
      • SDQSanto Domingo Las Americas Airport 18:10 - MDE 22:26 5h 16m 1 Stop (BOG) Bogota
      • SDQSanto Domingo Las Americas Airport 18:10
        BOGBogota Airport 21:24
      • BOGBogota Airport 19:50
        MDEMedellin Jose Maria Cordova Intl Airport 22:26
      • 5h 16m (1h 34m)
      • 1 Stop BOG · Bogota 1h 34m
      • Avianca (AV 251)Airbus
        Avianca (AV 9314)Airbus A320 Neo
      • Avianca (AV 251)
        • -
        • T
        • -
        • -
        • -
        • -
        • -
      • 18:10 SDQ
        23:42 MDE
        6Hrs, 32m 1 Stop (BOG)
      • SDQSanto Domingo Las Americas Airport 18:10 - MDE 23:42 6h 32m 1 Stop (BOG) Bogota
      • SDQSanto Domingo Las Americas Airport 18:10
        BOGBogota Airport 22:40
      • BOGBogota Airport 19:50
        MDEMedellin Jose Maria Cordova Intl Airport 23:42
      • 6h 32m (2h 50m)
      • 1 Stop BOG · Bogota 2h 50m
      • Avianca (AV 251)Airbus
        Avianca (AV 9342)Airbus
      • Avianca (AV 251)
        • -
        • -
        • W
        • -
        • F
        • -
        • -
      • 18:10 SDQ
        22:26 MDE
        5Hrs, 16m 1 Stop (BOG)
      • SDQSanto Domingo Las Americas Airport 18:10 - MDE 22:26 5h 16m 1 Stop (BOG) Bogota
      • SDQSanto Domingo Las Americas Airport 18:10
        BOGBogota Airport 21:24
      • BOGBogota Airport 19:50
        MDEMedellin Jose Maria Cordova Intl Airport 22:26
      • 5h 16m (1h 34m)
      • 1 Stop BOG · Bogota 1h 34m
      • Avianca (AV 251)Airbus
        Avianca (AV 9314)Airbus
      • Avianca (AV 251)
        • -
        • -
        • -
        • T
        • -
        • S
        • S
      No Schedules Sorry, there are no schedules matching your filters. Try removing one. reset
      What’s the fastest flight time from Santo Domingo to Medellin?

      The fastest flight time for direct flights from Santo Domingo to Medellin is 2 hours 29 minutes. Check latest flight schedules & prices on Wego.

      What’s the most popular airline flying from Santo Domingo to Medellin?

      The most popular airline flying from Santo Domingo to Medellin is Arajet. Find the latest flight deals on Wego.

      How far is Medellin from Santo Domingo?

      The flight distance between Santo Domingo and Medellin is 1493km. Check all available flights on Wego.

      When is the earliest and latest flight of the day?

      The earliest flight of the day departs at 05:21. The last flight of the day departs at 05:21. See the full list of flight times on Wego.

      How many airlines offer direct flights from Santo Domingo to Medellin?

      There are 2 airlines that offer direct flights from Santo Domingo to Medellin. Find out the list of airlines on Wego.

      Popular Airlines Flying From Santo Domingo to Medellin

      Arajet ‏()

      Popular Destinations From Medellin

      Popular Destinations From Santo Domingo

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